Figure 1 from Effects of Camellia Sinensis Extract on Repeated Restraint Stress-Induced Ovariectomized Female Rats | Semantic Scholar (2024)

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This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research and tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis.

The stress induced animal models intended to explain the mechanism of antidepressive nature of depression are presented and can be used as a guide to develop an accurate and precise animal model before start of any research work in which resembles the human disease conditions.

Results showed that treatments with PF caused significant reversals of the stress-induced deficits in learning and memory on a spatial memory task, and also increased the ChAT immunoreactivities.

O. sanctum and C. sinensis possess anxiolytic and antidepressant activities and significantly reduced the immobility times of rats in FST and TST.

Results reveal that specific ER-&bgr; agonists can ameliorate memory dysfunction and depressive behavior associated with postmenopausal diabetes and are devoid of the feminizing adverse effects of nonselective ER agonists.

No changes in anti-immobility activity in combination of subeffective doses of genistein and amitriptyline were observed and Genistein at its standard dose rendered synergistic effects in combination with subeffective dose of amitripyline (5 mg/kg).

A novel test procedure for antidepressants was designed in which a mouse is suspended by the tail from a lever, the movements of the animal being recorded, and the test can separate the locomotor stimulant doses from antidepressant doses.

If the endogenous estrogen levels in mice are maintained, an autologous endometriosis mouse model based on endogenous estrogen level can be induced in both proestrus/estrus and metestrus-diestrus cycle without any significant difference.

It is indicated that measuring P(4) or E(2) levels can predict many concurrent cellular and stromal events in the mouse uterus, suggesting that in naturally cycling mice cellular responses to hormone changes are not delayed, but occur very rapidly.

The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.

A systematic review of all available studies referenced in Medline from 1960 to 2011 found some evidence points to beneficial effects on glucose homeostasis of hydrazine-type monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs).

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